Methadone is a form of medicine called an opioid. Methadone is an opioid that is used mainly to wean people off their addiction to stronger opioids such as heroin. It is used as a substitution to these stronger opioids as those other opioids are far more dangerous. Methadone prevents the physical withdrawal symptoms that occur when these opioids (such as heroin) are stopped, this prevents the cravings of the drug. Overtime the individual is given gradually less and less of the drug methadone, untill it is completely absent. Although Methadone is addictive, it is less addictive than Heroin as it does not release endorphins as heroin does. This prevents addiction in most cases as it does not give the taker a 'high' as heroin does. Methadone is also sometimes prescribed for the relief of moderate to severe pain. It is also used for the treatment of severe coughs in terminally ill cancer patients i.e. people with lung cancer.
 Side Effects
There are several negative side effects from using Methadone including; Drowsiness, Confusion, Nausea and vomiting, Dry mouth, eyes or nose, Contracted pupils, Constipation, Difficulty passing urine, Decreased heart rate, rashes or itching, excessive sweating, abnormal, heartbeats and many more.
House uses Methadone near the end of season 5. He combines doseages of Methadone with Vicodin, this causes him to hallucinate after his heart had stopped. Although he stopped taking the Methadone when it caused him to 'be in a good mood' which prevented him from making the correct decisions when it came to a patient's life.
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